Indirect reduction techniques and fixation without opening the fracture zone to avoid disturbance of the blood flow- allow healing with relative stability and callus formation for the shaft fractures of the long bones. Intramedullary nails, percutaneous plates, minimally invasive plate osteosynthesis (MIPO) and external fixators are suitable implants for minimally invasive surgery in the treatment of this type of fracture. Although the first treatment of choice is often intramedullar nailing for the shaft fractures of the long bones such as femur, humerus and tibia, MIPO can be used for multi-fragmented or segmental fractures, or those extending to the proximal or distal shaft, as well as in case of medullary canal narrowing or deformity for which nailing is unsuitable or under other certain circumstances. The development of MIPO technique has led to the protection of the periosteal circulation, increased angular stability through locking screws and reduced loosening around the screws. However, some tips should be considered regarding the application of MIPO technique.