Diabetes patients often develop foot wounds, and these wounds frequently get infected. These infections cause considerable morbidity, mortality, and are often the proximate cause of lower extremity amputations. The major predisposing factor causing these infections is foot ulceration, which is usually related to peripheral neuropathy. Peripheral vascular diseases and various immunological disturbances play a secondary role. Several recently published guidelines can assist clinicians in managing these infections. The etiologic agents of infection have been well-defined, and these can be anticipated by epidemiological and clinical clues. Aerobic Gram positive cocci (especially Staphylococcus aureus) are the predominant pathogens in diabetic foot infections. Patients who have chronic wounds or recently received antibiotic therapy may also be infected with Gram negative rods, and those with foot ischemia or gangrene may have obligate anaerobic pathogens. Additionally, bone infection is an important problem for these patients. In this review, causative bacteria and approaches for diabetic foot infections are presented.