Joint diseases, especially osteoarthritis is among the leading social and economic burdens in increased elderly population of the modern world. Today, this global epidemic which adversely affects quality of life and health span of `baby boomer` generation, necessitates the development of joint preservation methods. It is crucial to focus on joint physiology and the pathophysiological basis of joint diseases in order to have a better understanding for the treatment approaches as well as improve effective preservation strategies for those with limited inherent regeneration capacity.