The musculoskeletal system is the system most frequently subjected to traumatic injuries due to its anatomical structure and functional role. The nature of injuries occurring in the musculoskeletal system varies depending on the severity of the trauma. The healing of bone or soft tissue damage follows a cascade that begins with inflammation and concludes with remodeling. Numerous factors influence this healing process, which can include local changes at the site of injury as well as effects on the systemic inflammatory process. During the healing phase, not only do biological changes occur, but mechanical factors also play a significant role, often as critical as biological factors in the healing mechanism. Unlike other tissues, bone tissue has the ability to fully return to its pre-injury state. However, soft tissues cannot revert to their pre-injury state because their healing mechanisms involve repair rather than regeneration.