Reconstruction of the bone loss and restoration of limb function is one of the difficult fields of orthopedic surgery. Surgical strategy should be determined by considering the cause of loss and the expectations of the patient. Associated conditions (diabetes, chronic renal failure, etc.), cigarette addiction, the state of the immune system, and the presence of infection in the fractured area should be assessed at each stage. In this section we will talk about the approach to bone loss, and the procedures most commonly used for reconstruction (Masquelet method, bone transport, acute shortening and re-lengthening from the healthy segment, and combined techniques).