Skeleton is the most frequent site of metastases in patients with breast cancer. Bone metastases from breast cancer are associated with skeletal-related events (SREs) including pain, pathological fractures, spinal cord compression and hypercalcemia. To avoid serious SREs causing impairment in quality of life and survival, early diagnosis and prophylactic approach are required. Delays in the diagnosis and appropriate treatment of the patient will lead to a decrease in the quality of life and cause disabilities. Recently, some studies have focused on dedicator of cytokinesis 4 as a potential biomarker for risk of bone metastasis with early breast cancer. Treatment options for metastatic bone disease for these patients include bisphosphonates, denosumab, analgesics, hormonal therapy, radiotherapy, and surgical techniques. The ultimate goal of all these treatment modalities is to get patients back to their previous level of function as soon as possible. The purpose of this article is to discuss the evaluation of patients with breast cancer metastasis, and their orthopaedic treatment as a part of a multidisciplinary team.