Bone metastases are more common than primary bone tumors, and they constitute 70–80% of all malignant bone lesions. Tumors that rarely metastasize to bone can be listed as: gastrointestinal tract tumors (nasopharynx, stomach, duodenum, rectum, pancreas, gallbladder, hepatocellular, parotid, and larynx), urogenital system tumors (cervix uteri, ovary, corpus uteri, endometrium, testis, and bladder), nervous system tumors (medulloblastoma, astrocytoma, pineablastoma, and glioblastoma), multiple myeloma, malignant melanoma, lymphoma, mesothelioma, unknown primary tumors, and neuroendocrine tumors. Early diagnosis followed by early treatment of bone metastases is crucial for improving quality of life, and providing functional abilities. Surgical treatment is required in very rare cases; radiotherapy and chemotherapy, alone or in combination, often provide symptomatic relief. Pathological fractures require open fixation. The aim of surgery is to relieve pain, maintain functional status, keep the patient ambulatory, provide care, and ensure the patient`s well-being.