The first applications of regenerative biological therapies on musculoskeletal diseases were introduced in the 1930s. The aim of regenerative medicine is to heal pathology by imitating natural processes or enhancing the body`s physiology through bio-engineering. The four main components required for regeneration in orthopedic tissues are cells, morphogenetic signals, scaffolds, and the appropriate mechanical environment. Treatments such as Platelet-Rich Plasma (PRP), mesenchymal stem cell (MSC), biological scaffolds, growth factors, and their combinations are most frequently applied today in order to protect, restore or increase the function of damaged tissues and organs. Scaffolds play an important role in the repair of large cartilage or meniscal defects. In today`s scaffold designs, the ability of the scaffold to host stem cells and growth factors is also considered. Although the science of tissue engineering has come a long way in the last two decades, it is still progressing slowly due to legal reasons and is still open to development.