TOTBİD Dergisi

TOTBİD Dergisi

2023, Cilt 22, Sayı, 1     (Sayfalar: 024-030)

Current information on disc tissue healing

Abdullah Merter 1, Orhun Eray Bozkurt 1

1 Ankara Üniversitesi Tıp Fakültesi, Ortopedi ve Travmatoloji Ana Bilim Dalı, Ankara

DOI: 10.5578/totbid.dergisi.2023.04
Görüntüleme: 286
İndirme : 429

Intervertebral discs are structures that are subject to intense deformation, and the degeneration process is multifactorial and has not been fully elucidated. Cellular, biomolecular and genetic studies on disc healing have gained popularity in recent years. In the studies, regeneration strategies were performed as isolated annulus fibrosus and nucleus pulposus. Although implants and their derivatives have been tried as repair mechanisms especially for annulus fibrosus, mostly regeneration-oriented gene therapies and biomolecules have been focused on for nucleus pulposus. In particular, mesenchymal stem cells have an important place in studies. In this article, promising developments in the treatment of intervertebral disc degeneration are mentioned, although longerterm and large-scale studies are needed.

Anahtar Kelimeler : intervertebral disc; degeneration; disc healing