TOTBİD Dergisi

TOTBİD Dergisi

2023, Cilt 22, Sayı, 1     (Sayfalar: 055-060)

Recent evidence-based advancements in stem cell and stromal vascular fraction therapies for arthrosis

Ahmet Murat Bülbül 1, Oğuzhan Korkmaz 2

1 Fenerbahçe Üniversitesi, İstanbul
2 İstanbul Medipol Üniversitesi Tıp Fakültesi, Ortopedi ve Travmatoloji Ana Bilim Dalı, İstanbul

DOI: 10.5578/totbid.dergisi.2023.08
Görüntüleme: 497
İndirme : 397

Osteoarthrosis (OA) is a disease that goes with the degeneration of articular cartilage and affects millions of patients all over the world. This disease, which progresses with cartilage tissue degeneration, can challenge orthopedic surgeons in the treatment due to the lack of regeneration capacity of the cartilage tissue. As regenarative medicine develops, stem cell therapies, which we see more and more in clinical applications, can also be used in orthopedic and traumatology routine. Although stem cell sources are bone marrow, adipose tissue, synovium and umbilical cord stroma, stem cells originating from bone marrow and adipose tissue are frequently used. The mesenchymal stem cell-rich content of the concentrate obtained from the adipose tissue by lipoaspiration under local anesthesia, obtained after filtration or centrifugation, is called the stromal vascular fraction (SVF). In addition, bone marrow aspiration concentrate (BMAC), which can be collected from the iliac crest or tibia, is a frequently used source of mesenchymal stem cells. Good results can be observed after stem cell applications in arthrotic and cartilage damaged joints. The purpose of this review is to review stem cell applications in arthrosis joints in the light of current scientific evidence.

Anahtar Kelimeler : mesenchymal stem cell; stromal vascular fraction (SVF); osteoarthrosis