Soft tissue sarcomas (STS) are rare and heterogeneous tumors originating from different tissue types. In addition to the orthopedic oncologist experienced in diagnosing and treating these tumors, a multidisciplinary team including radiologist, pathologist, medical and radiation oncologist, sometimes plastic and reconstructive surgeon, and cardiovascular surgeon as needed should work together. This team should play an active role in the pre-diagnostic evaluation of the patient, planning of the biopsy, diagnostic stage after the pathological sample is taken, and personalized treatment planning after the diagnosis. Insufficient surgery, which is thought to be benign, increases the risk of local recurrence and associated metastasis in the patient. Improper removal of the tumor entails the need for more aggressive surgery in addition to the tumor bed removal. Inappropriate biopsy results in severe consequences that may lead to amputation. All these steps must be fully implemented. In this context, the process of applying the principles of surgical treatment is under the responsibility of the orthopedic oncologist, and it is a stage that includes other departments in the multidisciplinary team. This section highlights the main points that should be considered in the surgical treatment of soft tissue sarcomas.