Nowadays periprosthetic joint infections have become more prevalent parallel to the increasing number of arthroplasty operations. In the treatment of periprosthetic joint infections; some treatment modalities like irrigation and debridement, antibiotherapy, single or two-staged revisions are common practice. However, in failed cases with this treatment modalities, surgeons should bear in mind that using non-implantation treatment methods according to the duration of infection, the period of symptoms, the virulence of the pathogen, the status of the joint (bone loss or soft tissue problems etc.), the expectations of patient, immune status and comorbid factors of the patient (renal insufficiency, hepatic insufficiency, immunodeficiency, peripheral arterial disease etc.). Surgeons should consider that selection of the patients is the main factor in the success of these treatments.