In parallel with the developing technology, imaging of the musculoskeletal system has been improved rapidly and thus, playing an important role in diagnosing, and treating an increasing variety of bone and soft-tissue lesions. This high-yield technology does not mean everything, however one piece in the puzzle pertaining to the musculoskeletal system imaging. All aspects of this system (anatomy, physiology, biochemistry, etc.) and other basic evaluation methods should be known and used together. Imaging techniques should be optimally selected based on the clinical condition and the patient. As radiological imaging techniques can be complimentary, their pros and cons as well as limitations should be known. In this article, we presented a basic understanding of the major radiologic imaging modalities used in musculoskeletal system, their common imaging applications in clinical practice, advantages and disadvantages.