Clinical manifestations of specific infections in orthopaedics are not common. In our country, specific infections caused by Mycobacterium tuberculosis and Brucella melitensis are common. The treatment of musculoskeletal involvements of specific infections are time-consuming. However, clinicians should be careful about resistance that may develop against the drugs. Operative intervention is one of the prefered treatments during the course of the diseases. The use of implants during surgery in tuberculosis cases is still controversial due to the joint problems that develop on chronic stage.