TOTBİD Dergisi

TOTBİD Dergisi

2010, Cilt 9, Sayı, 3     (Sayfalar: 175-178)

Cartilage tissue engineering

Feza Korkusuz 1, Metin Doğan 2, Murat Bozkurt 3

1 Orta Doğu Teknik Üniversitesi, Biyomedikal Mühendisliği Bölümü, Ankara
2 Ankara Atatürk Eğitim ve Araştırma Hastanesi, 4. Ortopedi ve Travmatoloji Kliniği, Ankara
3 Ankara Etlik İhtisas Eğitim ve Araştırma Hastanesi, Ortopedi ve Travmatoloji Kliniği, Ankara

Görüntüleme: 273
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İndirme : 325

Joint cartilage has a limited regeneration capacity. Joint wash-out, debridement, abrasion, subchondral bone drilling or microfracture techniques trigger fibrous instead of hyaline cartilage tissue. Cartilage tissue engineering combines chondrocytes, synthetic and/or natural matrices and/or signaling molecules. These modalities can be used alone or in combination. Matrix-induced autologous chondrocyte implantation and/or transplantation has been frequently used recently in the regeneration of chondral defects. Chondrocytes can be combined with natural or synthetic matrices for this purpose. Results of the procedure, however, lack strong evidence of superiority over current surgical procedures frquently used in clinical practice. Indications, contraindications, applications, follow-up, potential complications and information on rehabilitation of autologous chondrocyte implantation are selected in this manuscript. Future prospective, longitudinal, randomized-controlled multi-center studies will provide high level evidence to the outcomes of this high-technology cutting edge method.

Anahtar Kelimeler : Autologous chondrocyte implantation; chondrocyte; tissue engineering