For defects smaller than 2-3 cm2, microfracture method may be used, and if a more effective solution is desired, ostochondral autogenous transfer may be performed. Autologous chondrocyte implantation and matrix guided autologous chondrocyte implantation are suitable for 2-10 cm2 lesions. Ostochondral autogenous transfer may be suitable for smaller lesions. Autologous chondrocyte implantation is more appropriate for patients younger than 25 years old with 4-5 cm2 defects that do not disrupt the subchondral bony plate. Osteochondral autogenous transfer is recommended for revision of such cases. Osteochondral autogenous transfer and mosaicplasty are second line treatment techniques for defects under 3 cm2. Osteochondral autogenous transfer is a more appropriate choice for patients over forty with large defects involving the subchondral bone. Because osteochondral autogenous transfer and microfracture results are not satisfactory for patellofemoral lesions, autologous chondrocyte implantation should be preferred.