Implant-related infections are those that negatively affect the quality of life of the patient and have high treatment costs. After the infection, which mostly occurs during the surgical procedures, with the contamination, the traditional treatment method is debridement to the infection site after the implant is explanted and the antibiotic treatment administered intravenously to the patient for about 4–6 weeks. The types of pathogens that cause infection are quite diverse, many of which have the ability to create biofilm, a three-dimensional structure that protects themselves from external environments and allows them to multiply and spread. Since biofilm formation makes infection treatment very difficult, it is one of the main points of treatment to prevent the formation of biofilm in the early period. However, due to the decreased blood circulation in the infection area and the need for high doses of antibiotics to combat biofilm controlled antibiotic release systems are becoming more and more important day by day. Since these systems carry the antibiotic directly to the infection site, they do not cause any toxic reactions and the infection can be controlled more easily. Controlled antibiotic release systems can be manufactured alone or with multiple uses of different biomaterials, and can be used as implants alone or by coating on the surface of metal implants.