TOTBİD Dergisi

TOTBİD Dergisi

2020, Cilt 19, Sayı, 5     (Sayfalar: 675-681)

Current approach to experimental osteomyelitis models

Fehmi Volkan Öztuna 1-2, Ender Gümüşoğlu 1

1 Mersin Üniversitesi Tıp Fakültesi Hastanesi, Ortopedi ve Travmatoloji Anabilim Dalı, Mersin
2 VM Medical Park Mersin Hastanesi, Mersin

DOI: 10.14292/totbid.dergisi.2020.83
Görüntüleme: 305
İndirme : 279

Numerous experimental osteomyelitis models have been developed to set therapeutic targets, test new vaccines and antimicrobial compounds, and identify factors limiting model therapy such as biofilm formation and bone destruction. Historically, animal models of osteomyelitis; based on assisted pathogenesis measurements such as radiography, histology, clinical scoring systems, and semi-quantitative measurements of pathogen burden. We highlight new developments in experimental models of osteomyelitis, with a focus on quantitative bacteriologic and imaging tools, modeling of biofilm growth and strategies for local antimicrobial delivery.

Anahtar Kelimeler : experimental; osteomyelitis; in vivo, in vitro