We aim to provide information regarding the properties and use of antibiotics that are frequently used to treat orthopedic infections. Infection is a preventable complication that is frequently observed in patients undergoing orthopedic surgery during the postoperative period. Orthopedic infections lead to increased financial and psychosocial problems and are a significant cause of morbidity. Depending on the area and the pathological condition, the strain that causes the infection and the treatment to be administered may change. In addition, infections negatively affect the treatment process by disrupting the normal orthopedic progress. The rate of infection after total knee and hip arthroplasties varies between 1% and 5%, whereas that after an orthopedic trauma varies between 5% and 10%. The treatment is negatively affected, particularly due to the increasing number of resistant bacterial strains. Therefore, it may be necessary to administer long-term antibiotherapy or combination antibiotic regimens in such cases. Papers and published medical journals or books on orthopedic infections and the use of antibiotherapy in such infections were reviewed. The reviewed papers and book sections contained infections associated with total joint arthroplasty, sports surgery, trauma, and pediatric orthopedics as well as leg-ankle, shoulder-elbow, and hand infections. Papers on infections in orthopedic oncology were excluded. The antibiotic resistance in musculoskeletal infections is increasing, requiring the selection of a suitable antibiotic and its use in such a way that does not induce resistance to the antibiotic. In addition, the use of combination antibiotic therapy in patients with antibiotic resistance may be required.