TOTBİD Dergisi

TOTBİD Dergisi

2020, Cilt 19, Sayı, 5     (Sayfalar: 758-765)

Bone infections and treatment of bone infections using silver-ion containing nano-hydroxyapatite

Nusret Köse 1, Aydan Ayşe Köse 2, Ayşe Gül Toktaş 3, Aydın Doğan 3

1 Eskişehir Osmangazi Üniversitesi Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı, Eskişehir
2 Eskişehir Osmangazi Üniversitesi Tıp Fakültesi, Plastik ve Rekonstrüktif Cerrahi Anabilim Dalı, Eskişehir
3 Eskişehir Teknik Üniversitesi, Malzeme Bilimi ve Mühendisliği Bölümü, Eskişehir

DOI: 10.14292/totbid.dergisi.2020.92
Görüntüleme: 493
İndirme : 1234

Although the cleaner surgical environment, antibiotic use, and surgical asepsis-antisepsis have reduced the incidence of infections during surgery, the risk of implant-related infections is still high. Surgical site infections, a common complication after all surgical procedures, are usually caused by the exogenous and endogenous microorganisms that enter the wound during the surgical procedure. It is a potential complication associated with any type of procedure and are among the most preventable health careassociated infection. Surgical site infections are usually localized to the incision site, but may extend into deeper structures, including musculoskeletal tissues. In orthopedic surgery the ability of the implants (joint prosthesis, intramedullary nail, external fixator, etc.) to be used for many years depends mainly on the integration of the implant with the bone and no infection in the surrounding areas. The ideal antimicrobial agent for infections should be able to reach high local concentrations without causing systemic toxicity and should not interfere with bone regeneration and implant integration with biological tissues. Despite the use of very high doses of antibiotics for implant-related infections, a relatively lower drug concentration was achieved at the target site and the success rate was not high. Since implant-related infections occur mainly in the tissues directly surrounding the implant surface, it is wiser to transport antimicrobials locally to prevent and treat these infections. Methods that prevent microbes from adhering to the surface of the implant are preferred for the prevention of infections. Given the high risk of antibiotic resistance associated with antibiotic-loaded coatings and other problems, non-antibiotic substances are a much more attractive alternative. Among the various substances, silver ion is a substance that come forward because it prevents bacterial attachment, its broad antibacterial spectrum (both gram negative and positive bacteria) has a long-term antibacterial effect and is less prone to resistance development.

Anahtar Kelimeler : nano-hydroxyapatite; silver; bone infection