Implant related infections are the most common musculoskeletal system infections. Infection usually comprises with a post-traumatic fractures or after surgery. As a result of contamination of microorganisms, a focal infection point may occur in the bone and joint and it can be distributed through the blood. The formation of biofilms on the implant surface causes the consist of resistance against antibiotics and therefore the necessity of different approaches in treatment. Hydroxyapatite is the amorphous crystalline main inorganic component of the extracellular matrix of bone. Due to their high osteoconductive properties, they are widely used as surface coatings in implants in order to increase bone-implant adhesion. Different properties (antibacteriality, osteoinductivity, strength, etc.) can be added to hydroxyapatite by various drugs, growth factors, polymers, and minerals. Boron is a type of mineral that can be found in different forms such as boric acid and borate in nature. It is known that boron has antibacterial properties. It can be considered that implant-related infections can be targeted and prevented by using the antibacterial boron with the nanometer-sized hydroxyapatite crystals that are osteoconductive materials, in implant production stages. In this review, the studies in which boron and hydroxyapatite are applied against implant related infections are summarized.