TOTBİD Dergisi

TOTBİD Dergisi

2017, Cilt 16, Sayı, 1     (Sayfalar: 001-004)

Legg-Calvé-Perthes disease; etiology and physiopathology

Hakan Ömeroğlu 1, Ulukan İnan 2

1 TOBB Ekonomi ve Teknoloji Üniversitesi Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı, Ankara
2 Eskişehir Osmangazi Üniversitesi Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı, Eskişehir

DOI: 10.14292/totbid.dergisi.2017.01
Görüntüleme: 541
İndirme : 417

Legg-Calvé-Perthes disease is a childhood disorder in which specific clinical and radiological findings due to disruption in the arterial circulation of the capital femoral epiphysis are seen. It is most commonly seen in children between 4 and 8 years of age and is 4–5 times more common in boys than in girls. Hereditary influences, delay in bone maturation, blood coagulation abnormalities, type II collagen mutation, hyperactivity/attention deficit disorder, trauma, exposure to smoking are the main factors which are considered to correlate with the origination of the disease. However, it is currently believed that the origin is probably multifactorial. Synovitis, necrosis in deep layers of the articular cartilage, necrosis, resorption and new bone formation coupling (being the bone resorption more dominant) in the bone epiphysis, disruption in the physis and metaphyseal changes are the main histopathological findings.

Anahtar Kelimeler : Legg-Calvé-Perthes disease; etiology; physiopathology