Periprosthetic infection developed after total knee arthroplasty is the most common cause of the revision surgery. Although there has been a lot of research done on the diagnosis and treatment of infection before, there is no consensus on this topic. In case of infection that may occur after total knee arthroplasty, a detailed anamnesis should be taken from the patient, and a detailed physical examination should be performed with clinical suspicion of infection; radiological examinations which may be useful for diagnosis should be requested and evaluated. After the diagnosis of infection as a result of these evaluations, appropriate treatment should be performed with a multidisciplinary approach. The major surgical methods for infected knee arthroplasty in the world are as follows: treatment with the antibiotic suppression alone, suppression therapy with antibiotics and surgical debridement, removal and reimplantation (single stage, dual stage), resection arthroplasty, arthrodesis, and amputation.