Over the last 20 years, negative pressure vacuum assisted therapy has been widely used. This modality is often utilized in wound defects after implant surgery, soft tissue defects with impossibility of primary closure due to severe soft tissue injuries, as an adjunct for soft tissue granulation before delayed primary closure and flap reconstruction also in burn cases, ulcers due to diabetic foot, sore pressures and vascular compromise. Problems related to soft tissue coverage due to these reasons cause increased morbidity and hospital costs. The aim of this article is to summarize indications for negative pressure vacuum assisted therapy in osteomyelitis and its related soft tissue defects and to provide an overview of current literature.