Negative Pressure Wound Therapy (NPWT) is an increasingly popular wound care procedure for orthopedic traumas in recent years. Modern NPWT systems including pored sponge systems, pressured dressing systems, and vacuum pumps producing negative pressure are used in compound fractures, after surgical debridement in contaminated wounds as an additional therapy. In this review, it is aimed to point out the basic indications of NPWT clinical usage in orthopedic surgeries and wounds, and vacuum therapy.