The balance of the human skeleton is very well balanced thanks to the osteoblast and osteoclast found in the bone. This balance may be disrupted by tumors metastasizing to the bone. There are two main types of bone metastases: 1) Osteolytic, which damages the structure of the bone; 2) Osteoblastic type, characterized by the formation of new bone. All these types of metastases have features that disrupt the main structure of the bone. The metaphyseal part of the bone is adjacent to the epiphysis but under the growth plate, and consists of trabecular bone. Metaphysis has a sinusoidal vasculature that causes slow blood flow in blood vessels compared to capillary networks. This slow blood flow in vascular sinusoids is ideal for hematopoietic and lymphoid cells to move in and out of the bone, which is also used by cancer cells that metastasize to bone. In this section, the features and mechanism of metastasis of cancer cells to the metaphyseal region of the bone are discussed.