It is not easy to make correct diagnosis in a patient who has pain, numbness, tingling, sensory disturbances, weakness, electricity or burning symptoms in his/her hand. It is necessary to take detailed history, apply proper physical examination, and order useful diagnostic tests. However, these may not be enough to plan the treatment in such a clinical condition. In this review, the readers will find the details with practical clues for the overall management of compression neuropathies.