TOTBİD Dergisi

TOTBİD Dergisi

2017, Cilt 16, Sayı, 2     (Sayfalar: 070-076)

Neurophysiology of chronic pain

Meltem Uyar 1, İdris Köken 2

1 Ege Üniversitesi Tıp Fakültesi Anesteziyoloji ve Reanimasyon Anabilim Dalı, Algoloji Bilim Dalı, Bornova, İzmir
2 İzmir Tepecik Eğitim ve Araştırma Hastanesi, Algoloji Bilim Dalı, Bornova, İzmir

DOI: 10.14292/totbid.dergisi.2017.12
Görüntüleme: 1046
İndirme : 2789

Chronic pain is a maladaptive condition which lasts longer than 3 months and accompanies with affective, cognitive and motivational disorders. It leads to decreased functions and deterioration in life quality, and requires a multimodal treatment. Nociceptive, neuropathic or mixed pain could be chronic. Chronic pain involves a series of molecular and cellular progressions. Prolonged inflammation, peripheral sensitization and central sensitization alter pain transmission and process. Therefore, these mechanisms that cause development of chronic pain lead to differences in the progress of pain signal reception. In this study, these mechanisms causing pain turn into a chronic state are reviewed.

Anahtar Kelimeler : neurophysiology of chronic pain