Recently, the adult stem cell treatment has gained a great interest for cartilage lesions. Indeed, regenerative medicine has a growing implication in almost every medical specialty. First clinical application in our country has been realized in 2009, and with the new technologies in this field, treatments have increased since then. There are mainly two methods for the preparation of these biological products for regenerative treatments: obtaining cultured products by amplification of cells in GMP laboratories, or preparing regenerative cell concentrates directly from bone morrow and fat tissues which lets us use the product in a single procedure. For the orthopedic procedures mainly the scaffolds embedded with stem cell are constructed in local cartilage lesions with open surgery techniques, whereas intraarticular regenerative cell cocktail injections are preferred for degenerated joint problems.