Since soft tissue sarcomas are rare and have more than 50 subgroups, there are difficulties in their diagnosis and treatment. As in other malignant tumors, three fundamental treatments are applied in the soft tissue sarcomas: surgery, radiotherapy and chemotherapy. Many studies showed that radiation therapy improves local control and disease-free survival rate of soft tissue sarcoma patients. On the other hand successful dose distributions have been achieved with current radiotherapy techniques leading to decreased side effects. Rarely, radiotherapy is applied alone for curative or palliative purposes in cases where surgery cannot be performed due to concomitant diseases or widespread metastases. There is no consensus regarding the timing of radiotherapy. It is not clear whether radiotherapy should be administered before or after surgery, and the time between surgery and radiotherapy. In the current review, the timing and technique of radiotherapy treatment in soft tissue sarcomas are discussed and summarized.