Skin is a complex tissue that protects the structures it covers, supports homeostasis, and has the ability to regenerate itself. The loss of this skin barrier can lead to serious complications varying according to the type and extent of the injury. Extensive skin losses following burns, degloving injuries, and tumor excisions necessitate effective wound management strategies. Skin is composed of three main layers: epidermis, dermis, and hypodermis. Skin grafts are nourished through plasmatic circulation and can be either partial or full thickness. Partial thickness grafts include the entire epidermis and part of the dermis, whereas full thickness grafts encompass both layers completely. Partial thickness grafts generally heal faster and the donor site scars are less noticeable; however, they are less durable under mechanical stress. Full thickness grafts provide better aesthetic and functional outcomes but are more challenging to nourish and can only be harvested from limited areas. Grafts can be harvested using dermatome devices and expanded with the mesh technique. Meshing improves nourishment by preventing fluid accumulation under the graft, though it may negatively affect aesthetic outcomes. Skin grafts are crucial in managing significant skin losses. The choice of graft, harvesting technique, and application methods are critical for a successful healing process. The advantages and disadvantages of partial and full thickness grafts should be evaluated based on the characteristics of the wound to be treated. This review thoroughly examines skin grafting techniques and the types of grafts.