Skin and soft tissue infections are among the most common bacterial infections that make up about 10% of hospital admissions for infections in the United States. Skin and soft tissue infections can range from cellulitis to necrotizing fasciitis that threaten life and limbs. Although there are various classifications for skin and soft tissue infections, there is no universally accepted classification system. In this article, necrotizing and non-necrotizing skin and soft tissue infections are presented under two main headings.